In 1995 Guillory starred as Lady Felicia Marabel in the TV mini-series The Buccaneers. She starred as Lettice Knollys in the 2006 TV mini-series The Virgin Queen. In 2013 she had a recurring role as Mary Day in the TV series Luther. She has starred in the films Kiss Kiss (Bang Bang), Obvious, The Time Machine, Love, Actually, Resident Evil: Apocalypse, Silence Becomes You, Eragon, Resident Evil: Afterlife, The Big Bang, and Resident Evil: Retribution. Sienna was nominated for a Phoenix Film Critics Society Award for Best Ensemble Acting in Love Actually. She was named Britain’s Most Eligible Woman by readers of Esquire UK in 2001.
