From 1999 to 2002 she starred in the series Roswell. In 2008 she starred as Vanessa in the television series Quarterlife and in 2011 as Jo Pye in the series State of Georgia. In 2014 Delfino starred as Andi in the TV series Friends with Better Lives. She has been nominated for ALMA Awards in 1998 and 2000 and for a Young Artist Award in 2000. As a singer Majandra released her EP The Sicks in 2001. Her second album Tarte was released in 2007. Majandra is the younger sister of actress Marieh Delfino.
