Denison has also starred as Andy Flynn on the series Major Crimes starting in 2012. He has also had recurring roles on the TV series Wiseguy, Love and Marriage, Melrose Place, Playmakers, Prison Break, and more. Denison has also starred in several films including The Great Escape II: The Untold Story, City of Hope, The Amy Fisher Story, Getting Gotti, Criminal Passion, Pizza Man, and more. He won a Prism Award for The Closer in 2011 and was nominated for Screen Actors Guild Awards for The Closer in 2006, 2008, 2009, 2010, and 2011.