In 2001 she starred in the TV series Kristin as Santa Clemente. Ortiz starred in the 2003 series A.U.S.A. and in the series Over There in 2005. One of her best known roles was starring as Hilda Suarez in the series Ugly Betty from 2006 to 2010. Starting in 2013 Ana stars as Marisol in the series Devious Maids. In 2007 Ortiz won an ALMA Award and an Imagen Award for her supporting role in Ugly Betty. Ana has starred in the movies Labor Pains, Big Mommas: Like Father, Like Son, Sleeping with the Fishes, and Such Good People. She married Noah Lebenzon in 2007 and the couple has two children together.