She followed suit in 1997, landing roles in various other telenovelas. Reguera also made appearances in commercials, before beginning to work in full-length films, including those which are English-speaking roles. Some of her more notable roles include Nacho Libre, Empire State, Cop Out, Cowboys & Aliens, and two feature films that are set to be filmed in 2014, Jessabelle and The Book of Life. She has worked with various brands as a spokesperson, including Kahula liquer and CoverGirl, an American makeup company. Currently she can be seen on HBO as a love interest for one of the main characters on Eastbound & Down.